Abstract

This study delves into the therapeutic potential of two natural compounds, amentoflavone and bilobetin, by investigating their interactions with the BPIFB4 protein. BPIFB4, a member of the BPI fold-containing superfamily, has been associated with various biological processes, particularly in longevity and cardioprotection( LAV-BPIFB4). Molecular docking analyses revealed promising binding energies for amentoflavone and bilobetin with BPIFB4, suggesting favorable interactions.Additionally by pKCSM database are showed the predicted toxicity properties of amentoflavone and bilobetin respectively. This research contributes to the growing body of knowledge on natural compounds and their therapeutic implications in the context of vital biological processes. However, these findings underscore the need for further investigations, including in vivo studies and clinical trials, to validate the observed effects and explore the translational potential of amentoflavone and bilobetin in promoting cardiovascular health and longevity.

Key words: LAV-BPIFB4, Amentoflavone, Bilobetin, Docking analysis, pKCSM