African Research Journal of Biosciences
Editor-in-Chief: Prof. Marielle C. Schneider | ISSN:3006-7464 | Frequency: Biannual | Publication Format: Open Access | Language: English | Indexing/Listing :

Current Issue of African Research Journal of Biosciences

Volume 1, Issue 1, January 2024
Research Paper

Effects of Trypanosoma brucei on thyroid hormones in albino rats

| Open Access

Neftiya Yaduma1* ID logo, J.A. Wahedi2 ID logo, Z.M. Buba3, J. Joseph4 ID logo, A. Elihu5 ID logo, S.L. Kela6 and W.G. Yaduma7,8 ID logo

Afr.Res.J.Bio.Sc. 1(1) (2024) 21-33, DOI:
Received: 19/10/2023|Accepted: 08/01/2024|Published: 25/01/2024


Infections with trypanosomes bring about various modifications in the body. Thyroid hormone affects almost all body organs. Thyroids are secreted by the thyroid gland in three forms namely; triiodothyronine (T3), tetraiodothyronine (T4) and thyroid stimulating hormone (TSH). The aim of this research is to investigate the effects of Trypanosoma brucei on thyroid hormone and the functioning of liver and kidney in albino rats. The effect of T. brucei on these hormones was investigated by setting up two groups A and B (treatment and control) each comprising of ten albino rats. The control group were not infected by T. brucei while the treated group were infected. The concentrations of the thyroid hormones in serum were measured using Enzyme-Linked Immunosorbent Assay (ELISA) at seven-day interval for a period of twentyeight days. Data were analyzed using the graph pad prism. There were no significant changes (p>0.05) observed in the level of TSH in week 1 of the treated group (3.09 ± 0.14) compared to the control (2.77 ± 0.19). At week 2 there was also no-significant decrease (p>0.05) in TSH level (3.04 ± 0.20) compared to control (3.35 ± 0.13). At week 3, there is significant decrease in the treated group when compared to the control (2.74 ± 0.11 vs. 3.40 ± 0.13). In the first week of treatment T3 level was non-significant when compared to the control group (0.20 ± 0.02 vs. 0.23 ± 0.02); T3 level was significantly lower (p< 0.05) in the second week compared to the control (0.12 ± 0.01 vs. 0.23 ± 0.03). At week three T3 level was significantly lower (p<0.05) compared to the control group (0.15 ±0.01 vs. 0.19 ± 001). There was a non-significant decrease (p>0.05) in the level of T4 in the treated group when compared to the control group at week 1 (5.42 ± 0.23 vs. 5.60 ± 0.21). At week 2 T4 level was non-significantly lower (p>0.05) in treated group compared to group B (5.31 ± 0.25 vs. 5.87± 0.15). At week 3 group A significantly reduced (p<0.05) in the treated group compared to the control (4.81 ± 0.24 vs. 5.65 ± 0.10). In conclusion, Trypanosoma brucei infection depresses thyroid gland functions which causes reduced production of the thyroid hormones which in turn causes hepatic and renal toxicities in albino rats.

Key words: Thyroid hormones, Trypanosoma brucei, Infection, Albino rats

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